• Home
  • Company
    • Management
    • Board of Directors
    • Advisory Board
  • Technology
    • Publications
  • Partnering
    • Product Pipeline
  • News
    • IN THE PRESS: Cloud Pharmaceuticals CSO Shahar Keinan in "The Scientist"
    • Cloud Pharmaceuticals to Present AI-Based Drug Design at Conferences in May
    • Cloud Pharmaceuticals Wins U.S.-China Health Summit
    • Cloud Pharmaceuticals Selected Finalist in U.S.-China Health Summit
    • Cloud Pharmaceuticals forms Drug Design Collaboration with GSK
    • Cloud Pharmaceuticals CEO to Speak at Artificial Intelligence in Drug Development Congress 27-28 September 2017, London, UK
    • Cloud Pharmaceuticals CEO and CSO to Speak at AI Pharma Innovation
    • Cloud Pharmaceuticals CEO to Speak at the AI in Pharma Summit October17, 2017 in Boston.
    • Cloud Pharmaceuticals CEO and CSO to Speak at AI Pharma Innovation
    • Undruggable? Not to Cloud Pharmaceuticals
    • Cloud Pharmaceuticals Announces Design of Active Pro-Drug for Treatment of Crohn's Disease and Ulcerative Colitis
    • Cloud Pharmaceuticals COO to Discuss Digital Tools for Drug Discovery and Development at the 2016 BIO International Convention
    • Cloud Pharmaceuticals Appoints Neurological Disorder Expert Jeff Vaught to Its Advisory Board
    • Cloud Pharmaceuticals Strengthens Management Team with Appointment of Two C-Level Executives
  • Events
  • Contact
Cloud Pharmaceuticals
Connect with us:

News

Follow @CloudPharm
Cloud Pharmaceuticals Announces Design of Active Pro-Drug for Treatment of Crohn's Disease and Ulcerative Colitis

Results of Cloud Pharmaceuticals, University of Florida Department of Medicine, and Ben-Gurion Health Sciences collaboration to be published in Current Topics in Medicinal Chemistry

Research Triangle Park, NC (June 29, 2016) -- Cloud Pharmaceuticals Inc., a cloud-based drug design and development company, today announced the design of an active pro-drug for Crohn's disease and ulcerative colitis (Inflammatory Bowel Diseases; IBD). This design is the result of collaboration among scientists at Cloud Pharmaceuticals, the University of Florida (UF), and Ben-Gurion University of the Negev (BGU).

Phospholipid A2 (PLA2) is a membrane protein that is associated with intracellular trafficking. Studies have shown that PLA2 activity in severely inflamed mucosa of IBD patients is significantly higher than in normal colonic mucosa, and PLA2 may be exploited as a drug-activating enzyme, allowing drug targeting to the site(s) of gut inflammation.

Together, Cloud Pharmaceuticals, UF, and Ben-Gurion University devised a new way to design pro-drugs using free-energy perturbations to accurately predict the activation of phospholipid-drug conjugates by PLA2. Results of the collaboration have been accepted for publication in Current Topics in Medicinal Chemistry, 2016. In the manuscript, the calculated activity correlated with indomethacin-phospholipid conjugate in vitro experimental data. Based on calculations, novel designs of another PL-pro-drug set have been synthesized and show activity as predicted.

Dr. Shahar Keinan, Cloud Pharmaceuticals CSO, said: "We are very excited for developing and implementing this new computational capability, adding the development of pro-drugs to our current offering. This capability improves the speed and lowers the cost of designing novel drugs that are acutely needed to help patients with inflammatory bowel disease."
About University of Florida Health

University of Florida Health has two main campuses in Gainesville and Jacksonville. It includes two teaching hospitals and two specialty hospitals, as well as the colleges of Dentistry, Medicine, Nursing, Pharmacy, Public Health and Health Professions, and Veterinary Medicine, including both a large animal hospital and a small animal hospital. UF Health is the only academic health center in the United States with six health-related colleges located on a single, contiguous campus.

Patient-care services are provided through the private, not-for-profit UF Health Shands family of hospitals and programs. UF Health Shands Hospital in Gainesville includes UF Health Shands Children’s Hospital and UF Health Shands Cancer Hospital. The specialty hospitals, UF Health Shands Rehab Hospital and UF Health Shands Psychiatric Hospital, are also located in Gainesville. UF Health Jacksonville is the system’s northeast Florida center.

Dr. Ellen Zimmermann, Professor of Medicine and senior author on the recent manuscript, and Dr. Aaron Aponick in the Department of Chemistry spearheaded the UF team.  This project was funded, in part, by the Gatorade Trust. For information visit http://gastroliver.medicine.ufl.edu/ibd/.

About Ben-Gurion University of the Negev, Faculty of Health Sciences

Arik Dahan, PhD, Associate Professor of Pharmaceutics and Biopharmaceutics in the Department of Clinical Pharmacology and School of Pharmacy performed foundational work and was lead author on the recent manuscript in Current Topics in Medicinal Chemistry. The Faculty of BGU Health Sciences was founded in 1974 with the aim of revolutionizing primary care medicine in Israel through community involvement and the integration of medical education with medical care. This vision has developed into the reality of today's Faculty – a remarkable, interlocking network of research, teaching, and health-care institutions that has redefined compassionate health care. For information visit in.bgu.ac.il/en/fohs.

About Cloud Pharmaceuticals, Inc.

Cloud Pharmaceuticals is committed to improving health and well-being through the computational design and rapid development of new therapies. Its proprietary Quantum Molecular Design process combines artificial intelligence (AI) and cloud computing to search virtual molecular space and applies along sophisticated molecular modeling to design novel drugs. The process enables faster drug development progress at lower cost and a higher success rate and better targeting of hard-to-drug indications. The company partners at all stages of drug development – from discovery through the clinic – and is building an extensive product pipeline that spans a wide range of indications.
###
HOME | COMPANY | TECHNOLOGY | PARTNERING | NEWS | EVENTS | CONTACT

CONTACT US:

Cloud Pharmaceuticals, Inc.

Office: 800 Park Offices Dr., RTP, NC 27709
Mail: PO Box 110081, RTP, NC 27709
Phone: 1.910.398.1200
e-mail: info@cloudpharmaceuticals.com
CONNECT WITH US:


SUBSCRIBE:

Join our contact list to receive news and announcements in your inbox:

Join Now
© 2014 - 2019 Cloud Pharmaceuticals, Inc. | Terms and Conditions of access to www.cloudpharmaceuticals.com